Tc-43/nras-cypa-macrocyclic-glues-GA-II
NRAS–Cyclophilin A Macrocyclic Glue Designs (GA-II) Why this target matters. NRAS-mutant melanoma has no approved targeted therapy and poor outcomes once immunotherapy fails; RAS(ON) tri-complex glues are among the very few mechanisms that engage NRAS at all. 180 small molecules generated de novo by the Technetium TC-43.ai engine (GA-II), conditioned on the NRAS·Cyclophilin A protein–protein interface, with macrocyclic ring closure imposed during generation. Each molecule was… See the full description on the dataset page: https://huggingface.co/datasets/Tc-43/nras-cypa-macrocyclic-glues-GA-II.
| Author / organization | Tc-43 |
|---|---|
| License (as declared) | cc-by-4.0 |
| Downloads | 336 (as reported by Hugging Face) |
| Likes | 0 |
| Created | 13 August 2026 |
| Last updated at source | 16 September 2026 |
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