Tc-43/CyclinA_RXL_PPI_BLOCKER

Cyclin A RxL PPI Blockers — Ligand–Receptor Complexes Why this target matters. The cyclin A RxL groove is how cyclin–CDK complexes select their substrates, so blocking it offers a substrate-level selectivity that ATP-competitive CDK inhibitors — all competing for the same conserved pocket — cannot reach. 57 small molecules generated de novo by the Technetium TC-43.ai engine (GA-II), conditioned on the RxL substrate-recruitment groove of Cyclin A — a shallow protein–protein… See the full description on the dataset page: https://huggingface.co/datasets/Tc-43/CyclinA_RXL_PPI_BLOCKER.

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