Tc-43/Novel_NLRP3_Inhibitor_Designs
Novel NLRP3 Inhibitors — GA-II Designed Ligand–Receptor Complexes Why this target matters. NLRP3 sits upstream of IL-1β in gout, cardiovascular, metabolic and neurodegenerative disease, yet after two decades of effort no small-molecule NLRP3 inhibitor has reached approval. 176 small molecules generated de novo by the Technetium TC-43.ai engine (GA-II), conditioned on the allosteric site of the NLRP3 inflammasome NACHT module. Each molecule was constructed against this pocket… See the full description on the dataset page: https://huggingface.co/datasets/Tc-43/Novel_NLRP3_Inhibitor_Designs.
| Author / organization | Tc-43 |
|---|---|
| License (as declared) | cc-by-4.0 |
| Downloads | 354 (as reported by Hugging Face) |
| Likes | 0 |
| Created | 10 October 2025 |
| Last updated at source | 16 September 2026 |
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