Tc-43/THRB_Agonist_Designs_1R6G
THRβ Agonist Designs — 1R6G (GA-II) Why this target matters. Thyroid hormone drives lipid clearance and hepatic fat oxidation, but thyroid hormone itself is unusable as a drug because THRα engagement causes tachycardia, arrhythmia and bone loss. Resmetirom's 2024 approval for MASH proved that a β-selective thyromimetic can separate the metabolic benefit from the cardiac liability — and made β-over-α selectivity the whole game for this target. 188 small molecules generated de… See the full description on the dataset page: https://huggingface.co/datasets/Tc-43/THRB_Agonist_Designs_1R6G.
| Author / organization | Tc-43 |
|---|---|
| License (as declared) | cc-by-4.0 |
| Downloads | 134 (as reported by Hugging Face) |
| Likes | 0 |
| Created | 17 September 2026 |
| Last updated at source | 17 September 2026 |
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