Tc-43/Nav1.7_VSD4_NonAnionic_Designs_8I5G
Nav1.7 VSD4 Non-Anionic Designs — 8I5G (GA-II) Why this target matters. Human genetics validates Nav1.7 as thoroughly as any pain target in existence — loss-of-function carriers are congenitally insensitive to pain, gain-of-function mutations cause erythromelalgia — yet no Nav1.7 blocker has reached approval, and the clinical failures of the aryl sulfonamide class are widely attributed to the properties that come with its anionic warhead. 459 small molecules generated de novo… See the full description on the dataset page: https://huggingface.co/datasets/Tc-43/Nav1.7_VSD4_NonAnionic_Designs_8I5
| Author / organization | Tc-43 |
|---|---|
| License (as declared) | cc-by-4.0 |
| Downloads | 199 (as reported by Hugging Face) |
| Likes | 0 |
| Created | 16 September 2026 |
| Last updated at source | 16 September 2026 |
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