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Tc-43/Lipoprotein-a-Binder-Designs

Lipoprotein(a) Binder Designs — apo(a) KIV-8 / 8TCE Why this target matters. Lp(a) is the most common genetic cardiovascular risk factor in the world, affecting roughly a fifth of the population, and the only major one with no approved therapy. 100 small molecules generated de novo by the Technetium TC-43.ai engine (GA-II), conditioned on the lysine-binding site of kringle IV type 8 (KIV-8) of apolipoprotein(a), using the 1.07 Å co-crystal 8TCE — Lp(a) KIV-8 in complex with… See the full description on the dataset page: https://huggingface.co/datasets/Tc-43/Lipoprotein-a-Binder-Designs.

Author / organizationTc-43
License (as declared)cc-by-4.0
Downloads148 (as reported by Hugging Face)
Likes0
Created24 August 2026
Last updated at source16 September 2026
chemistrybiologydrug-discoverymolecular-dockinglipoprotein-acardiovascularkringlede-novo-designprotein-ligand-complexgenerative-designstructure-based-drug-designsyntheticsynthetic-dataai-generatedcomputational-chemistrycheminformaticsSMILESLPAapolipoprotein-aKIV-8molecular-property-predictionLp(a)apo(a)lysine-binding-site
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