VGL-stGen: Learning a shared multimodal model for lung histology and spatial transcriptomics
VGL-stGen is a multimodal large language model adapted from a pretrained medical vision-language model using paired lung H&E and spatial transcriptomics with single-cell references. Training integrates image-expression and expression-cell-type pairs, and gene-conditioned pseudo-labels transfer transcriptomic cell-type supervision to histology images. One deployed checkpoint supports thirteen evaluated tasks spanning tissue and cell-type classification, gene prediction and conditional expression completion from combinations of histology, cell identity and observed gene expression. Task-specific decoding produces categorical labels, gene lists and structured expression levels. For condition...
| Authors | Haenara Shin, Dongjoo Lee, Sungwoo Bae et al. |
|---|---|
| Primary category | cs.CV |
| Published | 20 October 2026 |
| Last updated at source | 20 October 2026 |
Silytics shows public metadata from arXiv and links to the original. Information may be incomplete or out of date. Last refreshed 21 October 2026. Licenses and terms of the original apply to the work itself. Not financial, legal or professional advice.