ITU-DESC: a missingness-aware machine-learning dementia risk score in the UK Biobank cohort
Background: Existing dementia risk scores rely on fixed, pre-selected features and linear models, or ignore bias from informative missingness in cohort data. Here we introduce the Istanbul Technical University Dementia Risk Score (ITU-DESC), an explainable machine-learning score for incident all-cause dementia that combines broad feature selection across roughly 8,000 candidate features with explicit control of missingness bias. Results: We studied approximately 500,000 UK Biobank participants with a median follow-up of 16.6 years. We withheld missingness patterns from the model using unconditional random hot-deck imputation. We stabilized feature selection by repeating BorutaSHAP-based f...
| Authors | Abdullah Kavaklı, Faik Boray Tek |
|---|---|
| Primary category | cs.LG |
| Published | 19 October 2026 |
| Last updated at source | 19 October 2026 |
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