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Beyond Multi-Stage Pipelines: A Label-Correlation Ensemble for Multi-Label Retinal Fundus Disease Classification

Retinal fundus images frequently carry more than one disease, and public fundus datasets are heterogeneous and severely long-tailed. Clinical triage suggests a staged design, in which a screening gate, a disease-group router and group-specific classifiers operate in sequence, but it is unclear whether this hierarchy earns its complexity. We present a controlled comparison of three architectures on a unified 39-target label space built from RFMiD 1.0, RFMiD 2.0 and ODIR-5K (12,652 images): (i) a three-stage gated cascade of eight models, (ii) a flat model with 39 independent sigmoid outputs, and (iii) a label-correlation model that replaces the flat linear head with 39 learned label querie...

AuthorsMd Asif Uddin, Jannatul Ferdous, Asif Islam et al.
Primary categorycs.CV
Published16 October 2026
Last updated at source16 October 2026
cs.CV
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