Clinically Interpretable Biological Age Estimation Using CatBoost and SHAP with Continuous and Categorical Features from NHANES
Biological age (BA) captures inter-individual variation in physiological aging beyond chronological age (CA). Although machine-learning models have advanced BA estimation, many rely primarily on continuous laboratory biomarkers, and SHapley Additive exPlanations (SHAP) dependence plots are typically interpreted visually. We developed a clinically interpretable machine-learning framework for BA estimation using heterogeneous clinical data from the National Health and Nutrition Examination Survey (NHANES 2011-March 2020, N = 24,983 adults aged >= 18). A CatBoost regression model incorporated 44 demographic, laboratory, physical examination, and lifestyle predictors to estimate CA, defining ...
| Authors | Yanni Sun, Zheng Qu, Kevin Ren et al. |
|---|---|
| Primary category | cs.LG |
| Published | 14 October 2026 |
| Last updated at source | 14 October 2026 |
Popularity, last 2 days
0 now. Counts as reported by the source, snapshotted daily by Silytics.
Silytics shows public metadata from arXiv and links to the original. Information may be incomplete or out of date. Last refreshed 17 October 2026. Licenses and terms of the original apply to the work itself. Not financial, legal or professional advice.