TANGO: RNA Topology and Geometry Co-Design
Designing RNA sequences that satisfy target tertiary-structure objectives is an important problem in RNA engineering, with broad applications in synthetic biology and therapeutics. Existing 3D RNA design methods have made substantial progress, but they largely treat the target fold as a geometry-only objective. This is incomplete for RNA, whose functional folds are specified not only by tertiary geometry but also by secondary base-pairing topology. We therefore formulate RNA inverse design as a topology-and-geometry co-design problem and propose TANGO, a multi-objective multi-agent reinforcement learning framework for this task. TANGO adopts a staged curriculum: it first learns a topology...
| Authors | Tianmeng Hu, Biao Luo, Ke Li |
|---|---|
| Primary category | cs.LG |
| Published | 14 October 2026 |
| Last updated at source | 14 October 2026 |
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