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Paper · arXiv

BFHD: Bidirectional Feature Harmonization Decomposition for Heterogeneous Clinical Assessments

Clinical assessments are often collected using heterogeneous assessment systems across centers and time, leading to records that mix different but related sets of measurements. This motivates harmonization beyond total-score linking. We formulate clinical harmonization at the measurement level as a bidirectional recoverability problem: given paired observations from two assessment systems, the goal is to identify which measurements can be reliably translated in both directions within an application-defined tolerance, while separating non-translatable components. We propose Bidirectional Feature Harmonization Decomposition (BFHD), a feasibility-driven framework that enforces bidirectionall...

AuthorsYuanhao Zhuo, Zixi Qin, Ling Qin et al.
Primary categorycs.LG
Published14 October 2026
Last updated at source14 October 2026
cs.LG
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