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Paper · arXiv

Autonomous Science Bench: Evaluating AI Agents for Autonomous Scientific Discovery

AI agents for autonomous scientific discovery must decide which experiments to run under a limited budget. Most benchmarks for science agents provide fixed datasets, while others that support active experimentation largely rely on simulation. We introduce Autonomous Science Bench, an initial release comprising six budgeted design-build-test-learn campaigns grounded in published experiments across biology, chemistry, and materials science. Agents select batches of designs, receive measurements from a lab service, and use the results to guide subsequent experiments before delivering a predictive model. Success requires passing two calibrated gates: a discovery gate, which evaluates the desi...

AuthorsYibo Wen, Han Liu
Primary categorycs.AI
Published13 October 2026
Last updated at source13 October 2026
cs.AI
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