From Simulated Fluids to Living Tissue: Zero-Shot Foundation Model Transfer to Perturbed Embryos
Morphogenesis is driven by the interplay of genetic regulation and tissue mechanics. In vivo video data is limited, particularly under genetic mutations and environmental perturbations, making generalization beyond the most representative conditions in the dataset challenging. However, at tissue scales, the dynamics of Drosophila can be described as a continuum flow, motivating the usage of representations learned across other physical systems as priors for developmental dynamics. We investigate finetuning Walrus, a Continuum Dynamics Foundation Model pretrained across a broad set of simulated continuous systems, on tissue velocity fields from only 12 wild-type Drosophila blastoderm video...
| Authors | Louisa Cornelis, Haewon Jeong, Irina Espejo et al. |
|---|---|
| Primary category | cs.LG |
| Published | 12 October 2026 |
| Last updated at source | 12 October 2026 |
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