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Paper · arXiv

Large language model-generated patterns for epidemiological modeling: a multi-benchmark evaluation framework

Representing individual-level behavioral heterogeneity is challenging in epidemiological modeling, particularly when empirical behavioral data are sparse. We assess the potential of large language model (LLM)-generated behavioral outputs in addressing this challenge, using hepatitis C virus-related behaviors among people who inject drugs as a case study. Correspondence with epidemiological patterns was evaluated using external benchmarks: literature-informed association directions, correlations from an agent-based model (ABM), and survey associations. Across three LLMs, unconditional directional recovery across 28 retained literature-informed associations was 46-68%, compared with 82-93% ...

AuthorsSophia Mao, Keshav Gandhi, Alexander Gutfraind
Primary categorycs.AI
Published11 October 2026
Last updated at source11 October 2026
cs.AI
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