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Paper · arXiv

DyssomniaNN: Multi-Scale Spiking Neural Modeling of Human Sleep Disorders and Perceived Restedness

Clinical sleep medicine repeatedly documents profound divergences between objective sleep duration and subjective daytime impairment, notably exemplified by sleep state misperception in paradoxical insomnia and boundary instability in narcolepsy type 1. Here, we present DyssomniaNN: a multi-scale biophysical computational framework coupling Borbély's two-process regulation of sleep homeostasis and circadian drive with Saper's hypothalamic reciprocal flip-flop circuit and a recurrent corticothalamic leaky integrate-and-fire spiking neural network. We formalize five clinical cohorts across an identical 72-hour photoperiod: healthy control, circadian rhythm sleep-wake disorder (delayed-phase...

AuthorsDaniel Szelogowski
Primary categorycs.NE
Published9 October 2026
Last updated at source9 October 2026
cs.NEcs.ETcs.LGq-bio.NC
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