Beyond Action Entropy: Quotient-Space Exploration for Genome-Scale Metabolic Model Repair
Repairing scientific models from functional observations differs fundamentally from supervised prediction: feedback may certify a solution without revealing which structural correction is responsible. We study this setting for genome-scale metabolic model (GEM) repair, where multiple reaction edits can explain the same phenotypes and many apparently distinct edits correspond to the same biological mechanism. This many-to-one structure creates a hidden failure mode for conventional exploration: diversity in the output space need not translate into diversity of scientific hypotheses. We introduce QuotientPO, which collapses equivalent repairs into canonical mechanisms and optimizes explorat...
| Authors | Xuan Gong, Hanbo Huang, Wenbin Dai et al. |
|---|---|
| Primary category | cs.LG |
| Published | 8 October 2026 |
| Last updated at source | 8 October 2026 |
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