Label-free cell counting and viability prediction with brightfield imaging and deep learning
Cell viability assessment is a core requirement in cell culture systems, with critical applications in biopharmaceutical manufacturing and drug development. Conventionally, it is measured by adding membrane-impermeable dyes to a sample (a process called staining), which allows compromised cell membranes to be distinguished from intact ones. However, staining has several limitations: (a) chemical agents can perturb normal cellular processes of the cells being measured, (b) it is often ambiguous to assign viability to individual cells whose membrane integrity is only partially compromised. (c) photobleaching can undermine measurement accuracy over time when using fluorescent stains, and (d)...
| Authors | Amir Reza Vazifeh, Christian Zeigler, Sornanathan Meyyappan et al. |
|---|---|
| Primary category | cs.CV |
| Published | 7 October 2026 |
| Last updated at source | 7 October 2026 |
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