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Paper · arXiv

MedZERO: Self-Evolving Agents for Open-Ended Medical Reasoning Through Controlled Knowledge Accumulation

Large language models (LLMs) have shown promise in medical question answering and clinical reasoning, yet their improvement remains constrained by static parametric knowledge and costly expert supervision. Self-evolving agents offer a promising alternative by enabling models to improve through iterative task generation and problem-solving. However, most existing self-evolving methods are designed for easily verifiable domains such as mathematics and coding, where solutions can be checked by exact answers or executable programs. Medical reasoning is fundamentally different: it is open-ended, knowledge-intensive, and often only partially verifiable. We present MedZERO, a self-evolving frame...

AuthorsXilin Dang, Weilin Ruan, Xue Yang et al.
Primary categorycs.AI
Published6 October 2026
Last updated at source6 October 2026
cs.AI
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