dIon: Fragmentation-Based Invariance for Self-Supervised Learning of Tandem Mass Spectra

We introduce a novel invariance for peptide tandem mass spectrometry data, unlocking self-supervised representation learning that improves de novo sequencing of peptides. This invariance exploits the physical relationship between precursor properties (mass and charge) and fragment-ion evidence, without requiring peptide sequence labels. We introduce dIon, which adapts the DINO framework with two latent prediction tasks, both recovering a clean teacher representation: one from a spectrum mixture, using the precursor as a selection query, and one from a partial spectrum with the precursor withheld. The first associates precursor information with fragment-ion evidence; the second prevents re...

<iframe src="https://silytics.si/embed/item/1fd32c2d-b15f-4060-b0ab-ce2537a761e4" width="420" height="190" style="border:0" loading="lazy" title="Silytics entry"></iframe>

Silytics shows public metadata from arXiv and links to the original. Information may be incomplete or out of date. Last refreshed 17 October 2026. Licenses and terms of the original apply to the work itself. Not financial, legal or professional advice.