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Paper · arXiv

Repeated-Measure Leakage, Distribution Shift, and Reliability under Partial Observation in Patient World Models

Patient world models are increasingly proposed for longitudinal prediction, intervention-aware reasoning, and clinical-trial simulation. Causal or clinical intervention validity is distinct from predictive generalization and reliability; before making stronger claims, the underlying predictive state should generalize across patients, survive realistic shifts and missing observations, and expose failure through meaningful reliability signals. We evaluate these prerequisites in a deliberately narrow setting: short-horizon digital-biomarker forecasting from PhysioNet GaitPDB, comprising 165 participants, 306 recordings, and 51,129 context-future pairs. Using persistence, ridge, MLP, GRU, Tra...

AuthorsArjun Subramanian
Primary categorycs.LG
Published3 October 2026
Last updated at source3 October 2026
cs.LG
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