COMPASS: Comet Object Measurement Pipeline with Automated Selection and Scoring
Summary: The single-cell gel electrophoresis ('comet') assay is a widely used technique for quantifying DNA damage at the individual cell level. However, image analysis often relies on manual inspection or semi-automated software, which can be labor-intensive, difficult to reproduce, and sensitive to image quality and comet morphology. COMPASS automates comet assay image analysis by combining deep learning-based comet segmentation with damage measurement and automated comet selection. The pipeline produces standardized DNA damage measurements while offering robust detection, reducing manual effort and improving reproducibility through transparent selection and optional manual review. Avai...
| Authors | Jack Roberts, Canya Lu, Alexis Michelle Lawson et al. |
|---|---|
| Primary category | cs.CV |
| Published | 3 October 2026 |
| Last updated at source | 3 October 2026 |
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