From DNA Design to DNA Slimming: Auditable Agentic Discovery of a Deletion-Only Designer
Compact regulatory DNA can free up space in vector payloads, reduce synthesis and assay burden, and expose which sequence features drive predicted activity. Yet most model-based nucleic-acid designers optimize fixed-length sequences through substitutions; they do not ask which bases of an existing functional element can be removed while retaining predicted activity. We define the task of sequence slimming as selecting an exact-length, order-preserving subsequence while retaining activity. Modeled on the design benchmark NucleoBench, we propose a quantitative evaluation for slimming that balances sequence reduction with maintaining function. Each slimmer must return both the subsequence an...
| Authors | Joel Shor |
|---|---|
| Primary category | cs.LG |
| Published | 30 September 2026 |
| Last updated at source | 30 September 2026 |
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