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Paper · arXiv

Scalable Diffusion SBI for Compositional Inference under Simulator Misspecification

Simulation-based inference is challenging when many heterogeneous observations must be composed, hierarchical latent structure must be preserved, and the simulator is misspecified relative to observed data. We develop sampling and fine-tuning methods for diffusion-based inference in design-conditional settings, where the same simulator is queried across different experimental conditions $ξ$. We extend compositional score-based inference with a continuous-time diffusion coefficient that accounts for the number of observations, avoiding Jacobian and auxiliary-covariance corrections. We introduce Hierarchical Blockwise Diffusion Sampling (HBDS), which infers shared parameters and group-speci...

AuthorsVincent D. Zaballa, Elliot E. Hui
Primary categorycs.LG
Published29 September 2026
Last updated at source29 September 2026
cs.LGq-bio.QMstat.ML
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