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Paper · arXiv

GenomeOcean Anywhere: Private WebGPU Inference for Genome MoEs

Genome foundation models are most useful where sequences are generated, yet the largest models need datacenter accelerators and a place to send private DNA. We ask whether a 15-billion-parameter genome mixture-of-experts (MoE) model can instead run on volunteers' web browsers, with the experts spread across many untrusted devices, without changing its predictions and without revealing the sequence to any single device. We build a system in which a trusted coordinator runs attention and routing while browser workers run every expert feed-forward network through hand-written WebGPU kernels, and we protect the expert inputs with real-valued Lagrange coded computing: each worker receives only...

AuthorsGuang Yang, Fengchen Liu
Primary categorycs.CR
Published27 September 2026
Last updated at source1 October 2026
cs.CRcs.LGq-bio.GN
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