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Paper · arXiv

FOCUS: Benchmarking Retinal Model Generalization from Foundation Vision Encoders to Multimodal LLMs

Progress in AI-based retinal image analysis has advanced with foundation models, yet evaluating their reliability remains challenging. Performance reported on a single dataset does not capture how models behave under dataset shift, across clinical definitions, or for different patient subgroups. This limitation is particularly critical in medical imaging analysis, where robustness, calibration, and fairness are essential for safe deployment. We introduce FOCUS (Foundation Ophthalmic Cross-Dataset Understanding under Shift), a cross-dataset benchmark for evaluating retinal fundus models that considers vision-only encoder models (VM), vision-language dual-encoder models (VLM), and multimoda...

AuthorsDavid Restrepo, Chenwei Wu, Luis Filipe Nakayama et al.
Primary categorycs.CV
Published27 September 2026
Last updated at source27 September 2026
cs.CVcs.AI
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