Flow-Matching-Based Protein Structure Tokenizer Made Efficient and Easy
As the bridge between protein modality and discrete modeling, protein structure tokenization still largely relies on heavily engineered training objectives tailored to specific downstream tasks and large training datasets, which hinders its transfer to broader application scenarios. To address this issue, we propose ProFiT, a lightweight flow matching tokenizer. With simple training strategies that encourage healthy codebook utilization, ProFiT can be trained efficiently and naturally learns semantically meaningful representations without any manual semantic alignment, while achieving reconstruction quality and generalization that match or surpass those of substantially larger tokenizers....
| Authors | Zhe Zhang, Yikai Zhang, Jiangtao Feng et al. |
|---|---|
| Primary category | cs.LG |
| Published | 27 September 2026 |
| Last updated at source | 27 September 2026 |
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