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Paper · arXiv

Statistical Testing for Multiple Instance Learning via Selective Inference with Applications to Computational Pathology

Multiple instance learning (MIL) is widely used in computational pathology because it enables weakly supervised analysis of whole-slide images (WSIs) without requiring patch-level annotations. In attention-based MIL, instances with high attention scores are often interpreted as diagnostically important regions and used as visual explanations. However, attention scores alone cannot determine whether selected high-attention instances are significantly different from normal instances, limiting the reliability of attention-based explanations. In this paper, we formulate the evaluation of high-attention instances as a statistical hypothesis testing problem. Specifically, we assess whether a se...

AuthorsNoriaki Hashimoto, Shuichi Nishino, Teruyuki Katsuoka et al.
Primary categorycs.CV
Published21 September 2026
Last updated at source21 September 2026
cs.CVcs.LGstat.ML
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