Evaluating Transformation Models for pCLE Mosaic Registration
Confocal Laser Endomicroscopy (CLE) provides real-time, cellular-resolution optical biopsy but has a narrow field of view, which image mosaicing can extend to provide anatomical context. Because of line-by-line acquisition, probe motion, and probe-tissue interaction, frame alignment generally requires a non-linear transformation whose accuracy is difficult to quantify: flexible transformation models can fit intensity features and noise, so appearance-based metrics such as Normalized Cross-Correlation (NCC) can improve without a genuine gain in geometric accuracy. We therefore establish a dataset of 132 frame pairs across fourteen pCLE sequences from 4 patients with manually annotated land...
| Authors | Ahmed Aboelela, Johannes Barcsay, Jana Friedhof et al. |
|---|---|
| Primary category | cs.CV |
| Published | 21 September 2026 |
| Last updated at source | 21 September 2026 |
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