Democratizing Clinical Tumor Whole Genome Sequencing: 18-hour End-to-end Analysis via Trillion-parameter Large Language Models Locally Deployed on Consumer-grade Hardware
Whole genome sequencing (WGS) is essential for precision oncology, yet its clinical adoption remains limited by prohibitive computational costs and multi-day turnaround times. This work presents a fully localized low-resource framework enabling stable deployment of a trillion-parameter biomedical LLM on a single consumer-grade RTX 4060 laptop with 32GB system memory and 8GB VRAM, as well as on routine clinical workstations in general hospitals, completing the entire tumor-paired WGS workflow from raw FASTQ input to clinical-grade full-variation-spectrum report output. Under standard 30X depth configurations, our implementation finishes a single tumor-paired WGS analysis within 18 hours, a...
| Authors | Rui Xiao, Yili Xu |
|---|---|
| Primary category | q-bio.GN |
| Published | 14 September 2026 |
| Last updated at source | 14 September 2026 |
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