TotalSynth: Robust Whole-Body Synthetic CT from MRI and CBCT
Purpose: To develop and evaluate TotalSynth, a reusable pretrained framework for whole-body synthetic CT (sCT) generation from MRI and cone-beam CT (CBCT) images. Materials and Methods: In this retrospective technical study, the dataset was assembled between 2020 and 2026 from SynthRAD challenge data, four prostate cohorts, and BIC-MAC. After registration quality control, 1450 of 1800 public challenge pairs were retained; 350 were excluded for insufficient registration quality or major source/CT mismatch. The corpus also included 84 additional prostate MRI/CT and 60 external BIC-MAC MRI/CT cases. Three 5-fold model families were evaluated with image-domain, anatomy-aware, registration-bas...
| Authors | Valentin Boussot, Cedric Hemon, Anais Barateau et al. |
|---|---|
| Primary category | cs.CV |
| Published | 12 September 2026 |
| Last updated at source | 12 September 2026 |
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