Brain-PACE: A Deep Siamese MRI Framework for Modelling Longitudinal Brain Acceleration
Brain age estimation has become a popular research proxy for assessing brain health and disease, yet longitudinal trajectories of brain ageing are still poorly defined, and clinical use is limited. Building on existing Siamese longitudinal frameworks, we develop Brain-Predicted Age Acceleration (Brain-PACE) to directly estimate the pace of structural brain ageing from paired T1-weighted MRI. Brain-PACE identified accelerated ageing in $42.6$% of participants with mild cognitive impairment. Faster Brain-PACE was associated with greater functional and cognitive impairment (FAQ; $r=0.35$, ADAS13; $r=0.30$, CDR-SB; $r=0.32$) and greater regional tau burden in the posterior cingulate ($r=0.59$...
| Authors | Samuel Maddox, Jacob Newman, Saber Sami et al. |
|---|---|
| Primary category | cs.CV |
| Published | 10 September 2026 |
| Last updated at source | 10 September 2026 |
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