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Paper · arXiv

XAI-Refine: An Automated Explanation-Knowledge Loop for Brain-Age Prediction

Brain-age prediction models are commonly evaluated by predictive accuracy, yet accurate predictions alone do not establish that a model relies on reproducible or neurobiologically supported mechanisms. Post-hoc explanation methods can expose these mechanisms, but existing workflows typically stop at diagnosis or require correction targets to be specified before model analysis. We propose XAI-Refine, an automated explanation-knowledge loop for brain-age prediction from resting-state functional connectivity. At each iteration, XAI-Refine consolidates complementary post-hoc analyses across repeated training runs into reliable, structured model explanations. It converts each reliable explanat...

AuthorsYang Qiao, Junjie Wu, Deqiang Qiu et al.
Primary categorycs.LG
Published8 September 2026
Last updated at source8 September 2026
cs.LGq-bio.NC
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