FPicker: Topology-Guided Evolution for Filament Tracing in Low-SNR Microscopy
Automating filament tracing in Cryo-Electron Microscopy (Cryo-EM) is essential for 3D helical reconstruction but challenged by intersecting topologies and extremely low Signal-to-Noise Ratios ($\text{SNR} = σ_s^2/σ_n^2$ < 0.1 or -10 dB). Existing paradigms fail: pixel-wise segmenters suffer from severe topological fracturing, box-based detectors face ghost center drift, sequential trackers derail due to error accumulation, and traditional active contours collapse under artificial closed-curve constraints. To resolve these bottlenecks, we present FPicker, the first topology-guided framework reconciling these incompatibilities. It unifies perception via a center-endpoint representation and ...
| Authors | Tingyin Zhao, Mingtao Huang, Yuan Shen |
|---|---|
| Primary category | cs.CV |
| Published | 8 September 2026 |
| Last updated at source | 8 September 2026 |
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