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Paper · arXiv

OntologyBench: Can Dense Retrieval Satisfy Structured Biomedical Constraints?

We introduce OntologyBench, a tiered biomedical retrieval benchmark comprising 471,854 training and 125,744 evaluation query-document relevance pairs across concept grounding, relational retrieval, and compositional phenotype-based retrieval. Although these tasks can be tractable using ontology-aware reference methods, across task tiers, embedding performance is generally lower on relational and compositional tasks than on concept-grounding tasks. Fine-tuning on ontology-derived supervision improves performance on several relational and compositional tasks, whereas the evaluated reranking and LLM-based candidate-scoring methods provide little or no end-to-end improvement. Errors frequentl...

AuthorsXiao Yu Cindy Zhang, Wyeth Wasserman, Jian Zhu
Primary categorycs.AI
Published8 September 2026
Last updated at source8 September 2026
cs.AI
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