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Paper · arXiv

Benchmarking Clinical Decision Pathway Adherence in Large Language Models

Following clinical decision pathways (CDPs) defined by clinical practice guidelines is essential for safe and reliable medical decision-making. However, existing medical large language model (LLM) benchmarks mainly evaluate final-answer accuracy, providing limited evaluation of models' ability to adhere to guidelines. To address this gap, we introduce MEGA-CDP, a benchmark for evaluating whether medical LLMs can generate guideline-adherent CDPs using provided guidelines as references. MEGA-CDP is constructed from 2,274 English and Chinese clinical practice guidelines through a guideline-to-case pipeline, yielding 42,353 clinical cases with explicit reference CDPs. It supports both single-...

AuthorsNuo Chen, Xinyang Jiang, Zilong Wang et al.
Primary categorycs.CL
Published27 August 2026
Last updated at source27 August 2026
cs.CL
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