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Paper · arXiv

Agentic AI for operating scientific instruments for nanoscale characterization

Operating a scientific instrument such as an atomic force microscope (AFM) requires continuous expert decision-making. A trained user defines the experimental intent, translates it into instrument commands, assesses incoming data, adjusts imaging parameters, and post-processes the final image. Existing automation usually addresses only parts of this workflow through hard-coded routines, task-specific controllers, or trained machine-learning models. Here we present an agentic-AI framework that operates the executable part of the AFM workflow using a general-purpose, tool-augmented large language model connected to instrument functions through the Model Context Protocol (MCP). The framework...

AuthorsZahra Ayar, Marcos Penedo, Mahdi Mehdikhani et al.
Primary categorycs.AI
Published25 August 2026
Last updated at source25 August 2026
cs.AIphysics.ins-det
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