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Paper · arXiv

Real-time closed-loop protocol to assess neural variability in temporal coding

Understanding temporal coding in neural systems is essential for decoding brain communication and advancing knowledge of neural information processing. Neural activity often conveys information through spike sequences with stereotypical temporal structures linked to specific functions. However, these sequences are subject to variability introduced by neural dynamics. Real-time closed-loop stimulation is a powerful approach to study temporal coding through adaptive control. In this work, we evaluate how a closed-loop protocol adapts to this variability to drive neural dynamics toward a desired state. It computes the Victor-Purpura distance to quantify similarity between spike sequences gen...

AuthorsAlberto Ayala, Angel Lareo, Pablo Varona et al.
Primary categoryq-bio.NC
Published3 July 2026
Last updated at source3 July 2026
q-bio.NCcs.AIcs.NEeess.SPeess.SY
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