DNA Methylation Profiling in Melanoma: From Lesion Classification to Therapeutic Stratification
DNA methylation provides a stable record of cellular identity, capturing epigenetic programs that distinguish specialized cell states despite a shared genome. Because malignant transformation and tumour progression are accompanied by extensive epigenetic remodeling, we hypothesized that the methylome of melanocytic lesions contains biologically and clinically relevant information for both diagnosis and disease progression. In a cohort of 1,001 tissue samples prospectively collected across eight German university hospitals profiled using Illumina Infinium MethylationEPIC arrays, we compared machine-learning models based on selected Cytosine phosphate Guanine (CpG) methylation sites with mo...
| Authors | Jana T. Winterstein, Lukas Heinlein, Günter Raddatz et al. |
|---|---|
| Primary category | q-bio.GN |
| Published | 19 August 2026 |
| Last updated at source | 19 August 2026 |
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