Synthesizing Post-Acetazolamide Cerebral Blood Flow Maps from Baseline MRI in Moyamoya Using 3D Generative AI
For patients with Moyamoya disease, impaired cerebrovascular reserve (CVR) is an important hemodynamic criterion for recommending extracranial-to-intracranial bypass surgery. Standard CVR assessment in this cohort uses paired arterial spin labeling (ASL) perfusion MRI acquired before and after acetazolamide (ACZ). When ACZ is contraindicated or avoided, the post-ACZ cerebral blood flow (CBF) map needed for hemodynamic assessment is unavailable. We propose CAE3D, a deterministic 3D conditional autoencoder that synthesizes post-ACZ CBF maps directly from pre-ACZ ASL input. We evaluated CAE3D against ten comparators, including deterministic and diffusion-style 3D baselines, a 2D contextual b...
| Authors | Julia Huang, Camila Gonzalez, Rydham Goyal et al. |
|---|---|
| Primary category | eess.IV |
| Published | 14 August 2026 |
| Last updated at source | 14 August 2026 |
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