Label-Free Deep-Tissue Peripheral Nerve Detection with a Handheld Multimodal OCT Probe and NerveDetNet
Peripheral nerves buried beneath intact tissue are difficult to visualize during surgery and remain inaccessible to white light wide-field imaging and other surface optical imaging methods. Existing OCT nerve studies have largely relied on exposed nerves or polarization contrast with limited depth penetration, restricting their value for subsurface intraoperative guidance. Here, we introduce, to our knowledge, the first label-free framework for detecting peripheral nerves beneath unopened tissue and resolving their depth using intensity-based OCT structural signatures alone. The framework combines a handheld multimodal probe, integrating swept-source OCT with co-registered white light and...
| Authors | Yihan Wang, Ruilin You, Shaobai Li et al. |
|---|---|
| Primary category | physics.optics |
| Published | 13 August 2026 |
| Last updated at source | 13 August 2026 |
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