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Assessment of Conditional Diffusion Model for Synthetic Histopathology Image Generation

Synthetic histopathology image generation has emerged as an approach that may address data scarcity in computational pathology, yet current evaluation methodologies may not fully assess synthetic data quality for medical applications. This work investigates and addresses limitations in existing evaluation metrics, investigating an approach for assessing synthetic histopathology image quality through domain-specific metrics and downstream task validation. We show that conventional synthetic data evaluation metrics such as Frechet Inception Distance (FID) and Inception Score (IS) may have limitations when applied to histopathology images due to their reliance on ImageNet-pretrained feature ...

AuthorsSeyed Kahaki, Shijie Li, Weijie Chen et al.
Primary categorycs.LG
Published4 August 2026
Last updated at source4 August 2026
cs.LG
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