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Paper · arXiv

onepot-Bench 0: towards lab-aware in silico chemistry benchmarks

Language models are playing an increasingly important role in laboratory science, performing tasks such as experiment planning, execution, and post-hoc analysis. However, precisely measuring their abilities is difficult, as scientific capabilities require a mixture of both problem-solving skills and domain-specific intuition. Existing evaluations rarely measure the capabilities required to make reliable decisions in a physical laboratory and often rely on public data that may have appeared in model training corpora. We introduce onepot-Bench 0, a proprietary benchmark suite for evaluating language models on synthetic chemistry capabilities relevant to wet-lab execution. onepot-Bench 0 com...

AuthorsBrandon Wang, Andrei S. Tyrin, Daniil A. Boiko
Primary categorycs.LG
Published3 August 2026
Last updated at source3 August 2026
cs.LG
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