Three-Photon Bayesian Imaging of Ortho-Positronium
PET provides functional images relying on two-photon coincidences from positron-electron annihilation. In human tissue, about 40\% of annihilations are preceded by Ps formation, of which o-Ps component partially decays into three photons, with the remainder annihilating via pick-off or spin-exchange into two photons. This three-photon channel carries additional information about the surrounding micro-environment, including the three-to-two-photon yield ratio as a potential diagnostic marker. We propose the TRIO algorithm, a novel three-photon event-by-event image reconstruction algorithm formulated as a Bayesian maximum a posteriori inference problem. TRIO unifies time-based trilateration...
| Authors | L. Raczynski, W. Krzemien, A. Coussat et al. |
|---|---|
| Primary category | physics.med-ph |
| Published | 30 July 2026 |
| Last updated at source | 30 July 2026 |
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