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Paper · arXiv

OPERA: Offline Policy-guided Expert Routing and Adaptation for Universal Biomedical Image Analysis

Biomedical image analysis spans diverse modalities and tasks, yet real-world deployment is hindered by severe distribution shifts across scanners, protocols, and patient populations. High-performing models consequently require repeated domain-specific fine-tuning, which is a costly cycle that becomes impractical when labels are scarce or privacy constraints limit data sharing. We propose OPERA (Offline Policy-guided Expert Routing and Adaptation), a multi-agent ensemble framework that addresses this deployment bottleneck by treating expert weight assignment as an offline policy learning problem: a routing policy is learned from a small validation set without gradient updates to any expert...

AuthorsZihan Li, Feiyang Liu, Dandan Shan et al.
Primary categorycs.CV
Published27 July 2026
Last updated at source27 July 2026
cs.CVcs.AIcs.LGeess.IV
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