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Paper · arXiv

Simulation-Based Empirical Bayes

Empirical Bayes (EB) performs simultaneous inference across many related latent variables. Classical EB assumes that the likelihood p(x | z) is tractable. In many scientific applications, however, the likelihood is available only through a simulator. This paper develops EB for such implicit likelihoods. We introduce simulation-based empirical Bayes (SBEB), which connects nonparametric EB to simulation-based inference (SBI). SBEB computes EB estimates without an explicit density by using the observed data, simulator samples, and an amortized inference network. SBEB iteratively refines the fitted EB prior toward the population prior. With several scientific simulators and real-world data, w...

AuthorsXinwei Shen, Diana Cai, Cheng Zhang et al.
Primary categorystat.ML
Published23 July 2026
Last updated at source23 July 2026
stat.MLcs.LG
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