Antigen-specific Antibody Multi-modal Foundation Model for Functional Antibody Design
Antibodies are essential proteins that play a central role in immune recognition by binding specific antigen molecules. Although recent protein language models have enabled progress in single-chain protein modeling and generation, they often fall short in antigen-specific antibody design, where effective modeling requires explicit pairing between antibody and antigen, particularly at the epitope level. To address these limitations, we introduce AAMFM, an Antigen-specific Antibody Multimodal Foundation Model that learns unified representations of antibody sequences and structures conditioned on antigen context. AAMFM incorporates rich antigen information including geometric interfaces and ...
| Authors | Xiaoliang Shi, Zichen Wang, Runze Ma et al. |
|---|---|
| Primary category | q-bio.BM |
| Published | 22 July 2026 |
| Last updated at source | 22 July 2026 |
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