MechAInistic: An LLM-guided Multi-Agent System for Reasoning over Genome-Scale Constraint-Based Metabolic Models
Constraint-based metabolic modeling is a powerful way to study the mechanistic basis of cellular states and disease, but its effective use demands substantial computational expertise and careful coordination of multi-step analyses. We developed MechAInistic to lower this barrier and enable researchers to ask complex biological questions in natural language. Harnessing large language models, MechAInistic is a multi-agent system organized around an Architect-Reviewer pattern that transforms a natural-language question into an executable, model-grounded workflow and generates a structured report. The system supports a variety of tasks, including pathway comparison, perturbation analysis, dru...
| Authors | Josh Loecker, Narayna Puraja, William Bryan et al. |
|---|---|
| Primary category | q-bio.QM |
| Published | 8 May 2026 |
| Last updated at source | 8 May 2026 |
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