Recovering Candidate Circadian Regulators of Arrhythmic Pituitary Hormone Genes Using Reliability-Weighted Magnetic Laplacian with rwMagLap
We study how to recover candidate circadian-clock regulators of pituitary hormone genes that are important for women's health but do not show a clear 24-hour rhythm in bulk tissue, aiming to nominate clock-linked regulatory targets that could inform future chronopharmacologic and chronotherapeutic strategies. We propose \textbf{rwMagLap}, which builds a graph on rhythmic backbone genes. For each edge, we combine 24-hour fit quality with peak-time phase, represented as a complex unit-circle value, yielding a Hermitian adjacency matrix and a magnetic Laplacian. We insert arrhythmic hormone genes, treated as anchors, by a reliability-weighted nearest-neighbor projection. The projected anchor...
| Authors | Shabnam Sodagari, Nick Jasperson |
|---|---|
| Primary category | q-bio.QM |
| Published | 3 July 2026 |
| Last updated at source | 3 July 2026 |
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