CenSynCMB: Centre Maps and Physics-Guided Synthesis for Microbleed Detection
Cerebral microbleeds (CMBs) are MRI markers of small vessel disease and the microbleed component of amyloid related imaging abnormalities (ARIA-H), but their small size, sparsity, and similarity to vessels, calcification-like foci, and artefacts make automated detection difficult. We propose CenSynCMB, a centre-guided and mimic-aware framework combining a 3D Attention U-Net, auxiliary centre-map supervision, false-negative-driven reweighting, and fold-wise physics-guided synthesis of positive CMBs and labelled hard negatives. Synthetic data expose the detector to compact lesions and common mimics without validation or test leakage. On VALDO Task 2, CenSynCMB achieved the best local-compar...
| Authors | Lucas He, Hanyuan Zhang, Krinos Li et al. |
|---|---|
| Primary category | cs.CV |
| Published | 6 July 2026 |
| Last updated at source | 9 October 2026 |
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